Rock Paper Scissors memes follow a few consistent templates that have stuck around because they map onto real experiences. The most common one involves someone choosing a throw with complete confidence and getting beaten by the most obvious counter. The humor works because everyone has been that person. You commit to Rock with absolute certainty, the other person throws Paper, and you're standing there looking like you made a serious strategic decision and were still wrong.
The second major category is the game-theory meme: overthinking a two-second decision to the point of paralysis. "If I throw Rock, they'll expect Rock, so they'll throw Paper, so I should throw Scissors — but they know I'm thinking that, so they'll throw Rock, so I should throw Paper..." It goes on until the decision becomes as complicated as anything you'd see in actual game theory literature, applied to a three-gesture hand game. The joke is that the correct answer is "just be random" and that being random is actually very hard.
The third template is the "just throw Scissors" category — shorthand for whatever the speaker is confident always works, stated with the absolute certainty of someone who has won twice recently. This maps onto a real behavioral tendency. People who've had recent success with a particular throw start to feel like it's working because of skill rather than variance. The meme punctures that.
What makes RPS particularly good for meme content is that it's universally familiar. Every person on earth knows what the game is. The reference requires no setup. You can make a Rock Paper Scissors meme about any decision-making scenario — hiring, dating, foreign policy, sports strategy — and the audience immediately understands the analogy. The three-throw structure maps cleanly onto any situation with three options and no dominant choice.
The game's association with fast decisions made under uncertainty keeps generating new content. As long as people are in situations where they need to choose and have no clear basis for choosing, Rock Paper Scissors will be there as the reference point.